Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/96312
Type: Artigo de periódico
Title: Optimal Chemotherapy: A Case Study With Drug Resistance, Saturation Effect, And Toxicity
Author: Costa M.I.S.
Boldrini J.L.
Bassanezi R.C.
Abstract: A system of differential equations for the control of tumour cell growth in a cyclenonspecific chemotherapy is presented. A rate-of-kill term of saturation type, drug resistance, and toxicity are taken into account in a class of optimal control problems. Some results are obtained for general tumour cell growth rates. A detailed analysis is presented for the Malthusian cell growth, which shows a variety of optimal treatments according to the values of the model parameters and initial tumour level. © 1994 Oxford University Press.
Editor: 
Rights: fechado
Identifier DOI: 10.1093/imammb/11.1.45
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-77957185341&partnerID=40&md5=f4b311247bbbcf4a5f7d240c85b8adfe
Date Issue: 1994
Appears in Collections:Unicamp - Artigos e Outros Documentos

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