Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/96266
Type: Artigo de periódico
Title: Red Cell Membrane Protein Abnormalities In Hereditary Spherocytosis In Brazil
Author: Saad S.T.O.
Costa F.F.
Vicentim D.L.
Salles T.S.I.
Pranke P.H.L.
Abstract: We studied 14 kindred and nine unrelated patients from southeastern Brazil with the typical form of hereditary spherocytosis. Diagnosis was made on the basis of clinical features, presence of spherocytes on the peripheral blood smears and an abnormal osmotic fragility test. By densitometric tracing of SDS-PAGE stained by Coomassie blue, we detected isolated deficiency of spectrin in 39% of our patients, combined spectrin and ankyrin deficiency in 13%, and deficiency of band 3 in 13%. One of our patients presented ankyrin deficiency without spectrin reduction. Our data suggest that, despite ethnic differences among the Brazilian and European or North-American populations, these biochemical abnormalities in HS patients may be similar.
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Rights: fechado
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Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-0028091593&partnerID=40&md5=0a19cdf8c8d8a4785e24ba3a4cd276b4
Date Issue: 1994
Appears in Collections:Unicamp - Artigos e Outros Documentos

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