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Type: Artigo de periódico
Title: Clinical Study Of Efficacy, Safety And Adherence To Treatment Of Skin Infections With Roxithromycin Compared To Cephalexin [estudo Clinico Da Efetividade, Tolerabilidade E Aderencia Ao Tratamento Das Infeccoes De Pele Com Roxitromicina Comparada A Cefalexina]
Author: Macedo De Souza E.
Da Silva V.M.C.F.
Abstract: We have conducted a randomized, prospective and comparative clinical trial, in order to evaluate efficacy, tolerability and obedience to therapies for cutaneous infections, based in two different antibiotic drugs: roxithromycin (300 mg daily single oral dose) and cephalexin (500 mg 4 oral doses, each 6 hours). Both drugs were administered during a period of 7 days. Twenty eight patients completed the evaluation, being fourteen in each treatment group. The resolution of cutaneous lesions was complete in 57.1% of the patients receiving roxithromycin, against only 21.4% of those receiving cephalexin. The remain patients, presented all, considerable clinical improvement. Adverse reactions, of mild to moderate intensity, occurred in four patients receiving roxithromycin and one patient receiving cephalexin. The obedience to the therapeutic scheme was complete in 92.4% of the patients included in the roxithromycin group, against 85.7% of those included in the cephalexin group. The preference regarding the therapeutic scheme was directed in 96.3% of all patients (27 patients), to a single daily dose; against just one patient making option for multiple doses. In conclusion, we can consider roxithromycin as a good alternative for treatment of pyodermitis in out-house patients.
Rights: fechado
Identifier DOI: 
Date Issue: 1995
Appears in Collections:Unicamp - Artigos e Outros Documentos

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