Please use this identifier to cite or link to this item:
Type: Artigo de periódico
Title: Drug Kinetics And Drug Resistance In Optimal Chemotherapy
Author: Costa M.I.S.
Boldrini J.L.
Bassanezi R.C.
Abstract: A system of differential equations for the control of tumor cells growth in a cycle nonspecific chemotherapy is presented. First-order drug kinetics and drug resistance are taken into account in a class of optimal control problems. The results show that the strategy corresponding to the maximum rate of drug injection is optimal for the Malthusian model of cell growth (which is a relatively good model for the initial phase of tumor growth). For more general models of cell growth, this strategy proved to be suboptimal under certain conditions. © 1995.
Rights: fechado
Identifier DOI: 10.1016/0025-5564(94)00027-W
Date Issue: 1995
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File Description SizeFormat 
2-s2.0-0029240378.pdf776.84 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.