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Type: Artigo de periódico
Title: Enalapril Does Not Prevent The Myocardial Ischemia Caused By The Chronic Inhibition Of Nitric Oxide Synthesis
Author: Moreno Jr. H.
Nathan L.P.
Costa S.K.P.
Metze K.
Antunes E.
Zatz R.
De Nucci G.
Abstract: In rats, chronic administration of the nitric oxide (NO) inhibitor Nω-nitro-l-arginine methyl ester (L-NAME) causes arterial hypertension, cardiac hypertrophy and myocardial ischemic alterations such as necrosis and fibrosis. In this study, we evaluated the effect of 8 weeks of treatment with enalapril maleate on cardiac weight and on the development of the histological alterations induced by L-NAME. Enalapril significantly inhibited the development of both arterial hypertension (117.2 ± 5.8, 161.8 ± 8.8 and 122.0 ± 10.6 mm Hg, for control, L-NAME- and L-NAME + enalapril-treated animals, respectively) and left ventricular hypertrophy (1.36 ± 0.13, 1.60 ± 0.04 and 1.48 ± 0.05 mg/g, for control, L-NAME- and L-NAME + enalapril-treated animals, respectively), but had no effect on the myocardial lesions. These findings demonstrate that although the renin-angiotensin system plays a major role in the development of arterial hypertension and cardiac hypertrophy, it does not modulate the ischemia-induced myocardial alterations observed in this model. © 1995.
Rights: fechado
Identifier DOI: 10.1016/0014-2999(95)00625-X
Date Issue: 1995
Appears in Collections:Unicamp - Artigos e Outros Documentos

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