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Type: Artigo de periódico
Title: 2′fluoropolynucleotide-directed Reverse Transcriptase Reactions. Effect Of Homologous Polynucleotides
Author: Juca M.B.
Aoyama H.
Abstract: Several homologous polynucleotides have been tested as inhibitors on the reactions catalyzed by avian myeloblastosis virus (AMV) reverse transcriptase, in the presence of polyribonucleotides and 2′fluorinated polynucleotides as templates. Polynucleotides differentially inhibited the reactions catalyzed by reverse transcriptase in the presence of these synthetic templates. Polyriboadenylic acid (poly(rA), poIy(2′0-methyladenylic acid) (poly(Am)), poly(2′fluoro-2′deoxyadenylic acid) (poly(dAfl), polyinosinic acid (poly(rI)) and polyuridylic acid poly(rU)) inhibited the polyribonucleotide-, but not the 2′fluorinated polynucleotide-directed reverse transcriptase activity. © 1995 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
Editor: Informa Healthcare
Rights: fechado
Identifier DOI: 10.3109/14756369509020133
Date Issue: 1995
Appears in Collections:Unicamp - Artigos e Outros Documentos

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