Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/958
Type: Artigo de periódico
Title: Improved renal function after kidney transplantation is associated with heme oxygenase-1 polymorphism
Author: OZAKI, K. S.
MARQUES, G. M.
NOGUEIRA, E.
FEITOZA, R. Q.
CENEDEZE, M. A.
FRANCO, M. F.
MAZZALI, M.
SOARES, M. P.
PACHECO-SILVA, A.
CAMARA, N. O. S.
Abstract: Heme oxygenase-1 (HO-1) has a microsatellite polymorphism based on the number of guanosine-thymidine nucleotide repeats (GT) repeats that regulates expression levels and could have an impact on organ survival post-injury. We correlated HO-1 polymorphism with renal graft function. The HO-1 gene was sequenced (N = 181), and the allelic repeats were divided into subclasses: short repeats (S) (< 27 repeats) and long repeats (L) (>= 27 repeats). A total of 47.5% of the donors carried the S allele. The allograft function was statistically improved six months, two and three yr after transplantation in patients receiving kidneys from donors with an S allele. For the recipients carrying the S allele (50.3%), the allograft function was also better throughout the follow-up, but reached statistical significance only three yr after transplantation (p = 0.04). Considering only those patients who had chronic allograft nephropathy (CAN; 74 of 181), allograft function was also better in donors and in recipients carrying the S allele, two and three yr after transplantation (p = 0.03). Recipients of kidney transplantation from donors carrying the S allele presented better function even in the presence of CAN.
Subject: graft survival
heme oxygenase-1
polymorphism
renal graft function
renal transplantation
Country: Estados Unidos
Editor: WILEY-BLACKWELL
Citation: CLINICAL TRANSPLANTATION, v.22, n.5, p.609-616, 2008
Rights: fechado
Identifier DOI: 10.1111/j.1399-0012.2008.00832.x
Address: http://dx.doi.org/10.1111/j.1399-0012.2008.00832.x
http://apps.isiknowledge.com/InboundService.do?Func=Frame&product=WOS&action=retrieve&SrcApp=EndNote&UT=000259341800013&Init=Yes&SrcAuth=ResearchSoft&mode=FullRecord
Date Issue: 2008
Appears in Collections:FCM - Artigos e Materiais de Revistas Científicas

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