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|Type:||Artigo de periódico|
|Title:||Improved renal function after kidney transplantation is associated with heme oxygenase-1 polymorphism|
|Author:||OZAKI, K. S.|
MARQUES, G. M.
FEITOZA, R. Q.
CENEDEZE, M. A.
FRANCO, M. F.
SOARES, M. P.
CAMARA, N. O. S.
|Abstract:||Heme oxygenase-1 (HO-1) has a microsatellite polymorphism based on the number of guanosine-thymidine nucleotide repeats (GT) repeats that regulates expression levels and could have an impact on organ survival post-injury. We correlated HO-1 polymorphism with renal graft function. The HO-1 gene was sequenced (N = 181), and the allelic repeats were divided into subclasses: short repeats (S) (< 27 repeats) and long repeats (L) (>= 27 repeats). A total of 47.5% of the donors carried the S allele. The allograft function was statistically improved six months, two and three yr after transplantation in patients receiving kidneys from donors with an S allele. For the recipients carrying the S allele (50.3%), the allograft function was also better throughout the follow-up, but reached statistical significance only three yr after transplantation (p = 0.04). Considering only those patients who had chronic allograft nephropathy (CAN; 74 of 181), allograft function was also better in donors and in recipients carrying the S allele, two and three yr after transplantation (p = 0.03). Recipients of kidney transplantation from donors carrying the S allele presented better function even in the presence of CAN.|
renal graft function
|Citation:||CLINICAL TRANSPLANTATION, v.22, n.5, p.609-616, 2008|
|Appears in Collections:||FCM - Artigos e Outros Documentos|
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