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|Type:||Artigo de periódico|
|Title:||Synthesis And Crystal Structure Of Trans-3-(4-acetoxy-3-methoxyphenyl)-8-acetyloxy-2-methyl-2,3-dihydro-1,4- Benzodioxine|
De Azevedo N.R.
|Abstract:||A synthesis of the neolignan model compound 3-(4-hydroxy-3-methoxyphenyl)-8-hydroxy-2-methyl-2,3-dihydro-1,4-benzodioxine (3A) was achieved with high stereo- and regio-selectivity by oxidative coupling of phenols in the presence of Ag2O. The regiochemical assignments at C-8 were derived from a crystal structure determination by single-crystal X-ray diffraction analysis of diacetate SA, which could not be established unambiguously by NMR spectroscopy. Compound 5A crystallizes as colourless prisms in the monoclinic space group P21/a with a=11.524(2), b = 11.959(2), c=14.284(1) Å, α=90°, β=109.14(1), γ=90°, V=1860.3(5) Å3 and Z= 4. A final R-value of 0.059 was obtained.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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