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Type: Artigo de periódico
Title: Effect Of α-thalassemia And β-globin Gene Cluster Haplotypes On The Hematological And Clinical Features Of Sickle-cell Anemia In Brazil
Author: Figueiredo M.S.
Kerbauy J.
Goncalves M.S.
Arruda V.R.
Saad S.T.O.
Sonati M.F.
Stoming T.
Costa F.F.
Abstract: To compare the features of sickle-cell anemia in Brazil with those in other locales, we studied the effects of the β-globin-like gene cluster haplotype and α-thalassemia upon the clinical and hematological features in 85 patients, The distribution of haplotypes differed from that in the United States and Jamaica, The Central African Republic (CAR) haplotype predominated; 34% of patients were CAR haplotype homozygotes, 45% CAR/ Benin homozygotes, and 11% Benin homozygotes. No Senegal haplotype chromosomes were observed, α-thalassemia was present in 17.5% of patients, HbF levels were higher in Benin homozygotes, compared with the other two groups (P < 0.05). Nearly half the patients with a CAR haplotype had leg ulcers, compared to 12.5% of the Benin homozygote group; stroke did not occur in α-thalassemia carriers, but neither result was statistically Significant, As in other studies, our results indicate that the CAR haplotype may be associated with more severe disease.
Rights: fechado
Identifier DOI: 10.1002/(SICI)1096-8652(199610)53:2<72::AID-AJH3>3.0.CO;2-0
Date Issue: 1996
Appears in Collections:Unicamp - Artigos e Outros Documentos

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