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Type: Artigo de periódico
Title: Inhibition Of Microbial Metabolism By Ctab (cetyltrimethylammonium Bromide) And Its Effect On Cytoplasm Enzymes
Author: Ueno M.
Yokoya F.
Abstract: The effect of cetyltrimethylammonium bromide (CTAB) on the metabolism of various microorganisms was investigated. The rates of CO2 release and O2 uptake was inhibited by CTAB in a dose dependent fashion and were affected to variable degrees in the different microbial species, indicating that both respiratory and fermentative activities were inhibited. Pseudomonas aeruginosa, described as the most resistant of the tested microorganisms, was found to be 100 times less sensitive to CTAB with respect to metabolic activity. In contrast with intact cell responses, the activity of the enzyme lactate dehydrogenase extracted from sensitive and resistant species was equally inhibited by CTAB. Alcohol dehydrogenase was slightly more sensitive than lactate dehydrogenase. The concentration of CTAB required for complete inhibition of both enzymes was within the range of growth inhibition. This indicates that growth inhibition of microorganisms by CTAB could be due to its action on the metabolic activity of cytoplasm enzymes. Species resistance was related to differences in cell membrane permeability.
Rights: aberto
Identifier DOI: 
Date Issue: 1996
Appears in Collections:Unicamp - Artigos e Outros Documentos

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