Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/95277
Type: Artigo de periódico
Title: Chromobacterium Violaceum: A Review Of Pharmacological And Industiral Perspectives
Author: Duran N.
Menck C.F.M.
Abstract: Violet-pigmented bacteria, which have been described since the end of the 19th century, are occasionally the causative agent of septicemia and sometimes cause fatal infection in human and animals. Bacteria, producing violet colonies due to the production of a nondiffusible pigment violacein, were classified as a redefined genus Chromobacterium. Chromobacterium violaceum is Gram-negative, and saprophyte from soil and water is normally considered nonpathogenic to human, but is an opportunistic pathogen of extreme virulence for human and animals. The biosynthesis and biological activities of violacein and the diverse effects of this pigment have been studied. Besides violacein, C. violaceum produces other antibiotics, such as aerocyanidin and aerocavin, which exhibit in vitro activity against both Gram-negative and Gram-positive bacteria. 3,6-Dihydroxyindoxazene and Y-TO678h exhibit a selective activity against Gram-negative bacteria. Arphamenine A and B, and FR901228, that enhanced immunoresponse, and potentiators of β-lactam antibiotics and chelators such as ferrioxamine exhibit important clinical potential applications. Lipopolysaccharides and polyhydroxyesters together with several enzymes appear as important metabolites with biotechnological applications. Many of these metabolites were already studied at the genome level.
Rights: fechado
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-0034805976&partnerID=40&md5=03b1be93e75e5b3862c126158a41040e
Date Issue: 2001
Appears in Collections:Unicamp - Artigos e Outros Documentos

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