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Type: Artigo de periódico
Title: Delayed First Injection Of The Once-a-month Injectable Contraceptive Containing 25 Mg Of Medroxyprogesterone Acetate And 5 Mg Of E2-cypionate: Effects On Ovarian Function
Author: Petta C.A.
Hays M.
Brache V.
Massai R.
Hua Y.
Alvarez-Sanchez F.
Croxatto H.
D'Arcangues C.
Cook L.A.
Bahamondes L.
Abstract: Objective: To assess whether women who were administered the first injection of DMPA+E2C on day 7 of their menstrual cycle (delayed injection) exhibit the same degree of ovarian suppression as women who receive it on day 5 of their menstrual cycle. Design: Multicenter, randomized controlled trial.Setting: Reproductive health clinics. Patient(s): Women aged between 18 and 38 years (inclusive) willing to use DMPA+E2C as their method of contraception. Intervention(s): Participants received a DMPA+E2C injection on day 5 (control group, n = 41) or day 7 (delayed-injection group, n = 117) of their menstrual cycle. Main Outcome Measure(s): Ovarian activity and follicular development determined by serial serum progesterone levels and vaginal ultrasound. Result(s): Participants who received DMPA+E2C on day 5 of their menstrual cycle (control group) exhibited no more than limited follicular growth (no follicle >16 mm). Of those women who received DMPA+E2C on day 7 of their menstrual cycle (delayed-injection group), 21 (18%) showed some follicular growth, of whom 4 (3%) ovulated. Conclusion(s): The first injection of DMPA+E2C given on day 7 of a menstrual cycle does not provide the same inhibition of ovarian activity as that observed when it is administered on day 5 of the menstrual cycle. Copyright © 2001 American Society for Reproductive Medicine.
Rights: fechado
Identifier DOI: 10.1016/S0015-0282(01)01672-7
Date Issue: 2001
Appears in Collections:Unicamp - Artigos e Outros Documentos

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