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|Type:||Artigo de periódico|
|Title:||Mitochondrial Permeability Transition And Oxidative Stress|
|Abstract:||Mitochondrial permeability transition (MPT) is a non-selective inner membrane permeabilization that may precede necrotic and apoptotic cell death. Although this process has a specific inhibitor, cyclosporin A, little is known about the nature of the proteinaceous pore that results in MPT. Here, we review data indicating that MPT is not a consequence of the opening of a pre-formed pore, but the consequence of oxidative damage to pre-existing membrane proteins. © 2001 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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