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Type: Artigo de periódico
Title: Mitochondrial Permeability Transition And Oxidative Stress
Author: Kowaltowski A.J.
Castilho R.F.
Vercesi A.E.
Abstract: Mitochondrial permeability transition (MPT) is a non-selective inner membrane permeabilization that may precede necrotic and apoptotic cell death. Although this process has a specific inhibitor, cyclosporin A, little is known about the nature of the proteinaceous pore that results in MPT. Here, we review data indicating that MPT is not a consequence of the opening of a pre-formed pore, but the consequence of oxidative damage to pre-existing membrane proteins. © 2001 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.
Rights: fechado
Identifier DOI: 10.1016/S0014-5793(01)02316-X
Date Issue: 2001
Appears in Collections:Unicamp - Artigos e Outros Documentos

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