Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/95229
Type: Artigo de periódico
Title: The G209a Mutation In The α-synuclein Gene In Brazilian Families With Parkinson's Disease
Author: Teive H.A.G.
Raskin S.
Iwamoto F.M.
Germiniani F.M.B.
Baran M.H.H.
Werneck L.C.
Allan N.
Quagliato E.
Leroy E.
Ide S.E.
Polymeropoulos M.H.
Abstract: A missense G209A mutation of the alpha-synuclein gene was recently described in a large Contursi kindred with Parkinson's disease (PD). The objective of this study is to determine if the mutation G209A of the alpha-synuclein gene was present in 10 Brazilian families with PD. PD patients were recruited from movement disorders clinics of Brazil. A family history with two or more affected in relatives was the inclusion criterion for this study. The alpha-synuclein G209A mutation assay was made using polymerase chain reaction and the restriction enzyme Tsp451. Ten patients from 10 unrelated families were studied. The mean age of PD onset was 42.7 years old. We did not find the G209A mutation in our 10 families with PD. Our results suggest that alpha-synuclein mutation G209A is uncommon in Brazilian PD families.
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Rights: aberto
Identifier DOI: 
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-0035464075&partnerID=40&md5=ad7d4965720d70e168f94abde168bf44
Date Issue: 2001
Appears in Collections:Unicamp - Artigos e Outros Documentos

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