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Type: Artigo de periódico
Title: Baker's Yeast Reduction Of α-methyleneketones
Author: Siqueira Filho E.P.
Rodrigues J.A.R.
Moran P.J.S.
Abstract: The bioreduction of α-methyleneketones, R 1C(=O)C(=CH 2)R 2 (R 1 = Me, Et, Pr, iso-Bu, Ph, CH 2CH 2Ph; R 2 = Cl, Me, Et, n-Pr, iso-Pr, n-Bu, n-C 6H 13, Ph, CH 2Ph), was mediated by baker's yeast (Saccharomyces cerevisiae) to obtain the corresponding α-methylketones. The R 1 and R 2 groups had a significant influence on the rate and enantioselectivity of the reductions. The rate of C=C bond reduction was higher than that of C=O bond reduction. Only α-methyleneketones having R 1 = Me yielded α-methylketones in high enantioselectivity with e.e.s of 88-99%. © 2001 Elsevier Science Ltd.
Rights: fechado
Identifier DOI: 10.1016/S0957-4166(01)00134-3
Date Issue: 2001
Appears in Collections:Unicamp - Artigos e Outros Documentos

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