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Type: Artigo de periódico
Title: The role of glucocorticoid in SIRP alpha and SHP-1 gene expression in AIHA patients
Author: ALMEIDA, Ana Carolina de
BARBOSA, Soraya Massaro
BARJAS-CASTRO, Maria de Lourdes
OLALLA-SAAD, Sara Teresinha
Abstract: The aim of this work was to evaluate the regulation of SIRP alpha, an inhibitory phagocyte receptor, and the phosphatase SHP-1 in monocytes of patients with autoimmune hemolytic anemia, and the role of dexamethasone on SIRP alpha and SHP-1 gene expression and erythrophagocytosis in vitro. SIRP alpha and SHP-1 expression was higher in monocytes from AIHA patients compared with normal, returning to normal after glucocorticoid therapy. SIRP alpha and SHP-1 mRNA expression was upregulated in healthy monocytes treated with dexamethasone compared with basal; however, the erythrophagocytic ability was not altered. Our results point to a minor role of SIRP alpha and SHP-1 in determining AIHA.</.
Country: Estados Unidos
Citation: IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, v.31, n.4, p.636-640, 2009
Rights: fechado
Identifier DOI: 10.3109/08923970902939256
Date Issue: 2009
Appears in Collections:FCM - Artigos e Outros Documentos

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