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Type: Artigo de periódico
Title: Modulation Of The Severity Of Experimental Autoimmune Encephalomyelitis By γδ T Lymphocytes Activated By Mycobacterial Antigens
Author: Diaz-Bardales B.M.
Novaski S.M.S.
Goes A.E.
Castro G.M.
Mengel J.
Santos L.M.B.
Abstract: Immunity to mycobacterial antigens may contribute to the maintenance of self-tolerance. Exposure of the immune system to mycobacterial antigen might well stimulate the immune system to exert control over unwanted self-reactive clones. We demonstrated that in vivo administration of Mycobacterium tuberculosis, PPD, and PPD peptide (180-196) prior to immunization with Myelin Basic Protein (MBP) led to a moderate increase of γδ T cells, suppression of the immune response, and reduction in the severity of Experimental Autoimmune Encephalomyelitis. The immunosuppression observed is due, at least in part, to the production of Transforming growth factor-β (TGFβ) by the γδ T lymphocytes.
Rights: fechado
Identifier DOI: 10.1081/IMM-100105068
Date Issue: 2001
Appears in Collections:Unicamp - Artigos e Outros Documentos

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