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Type: Artigo de periódico
Title: Expression Of Epstein-barr Virus In Classical Hodgkin's Lymphomas In Brazilian Adult Patients
Author: Vassallo J.
Metze K.
Traina F.
De Souza C.A.
Lorand-Metze I.
Abstract: We studied the frequency of Epstein-Barr virus (EBV) expression in Hodgkin's lymphoma (HL) among 78 adult Brazilian patients and correlated it with clinical findings and survival. Latent membrane protein-1 (LMP-1) was detected by immunohistochemistry and EBV-encoded RNA (EBER) by in situ hybridization. EBV was expressed in 50 patients (64.1%), more frequently in those with mixed cellularity (MC). There was no relation between EBV expression and sex, age or stage of the disease. Expression of LMP-1 correlated with better overall survival (p = 0.02). EBV expression in adult patients with HL in our study was similar to that in other developing countries. Expression of LMP-1 was associated with better prognosis.
Rights: aberto
Identifier DOI: 
Date Issue: 2001
Appears in Collections:Unicamp - Artigos e Outros Documentos

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