Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/94985
Type: Artigo de periódico
Title: Synthesis, Antimycobacterial Activities And Cytotoxicity On V79 Of 3-[4′-y-(1,1′-biphenyl)-4-yl]-n,n-dimethyl-3-(4-x-phenyl)-2- Propen-1-amine Derivatives
Author: De Souza A.O.
Santos Junior R.R.
Ferreira-Julio J.F.
Rodriguez J.A.
Melo P.S.
Haun M.
Sato D.N.
Duran N.
Abstract: The derivatives of 3-(4′-bromo-[1,1′-biphenyl]-4-yl)-3-(4-X-phenyl)-N,N-dimethyl-2- propen-1-amine (5a-m) were synthesised through a Friedel-Crafts acylation followed by Wittig reaction. The effects of the compounds on standard strains of Mycobacterium sp. (ATCC) and M. tuberculosis isolated from clinical specimens were evaluated. Also the toxicity was determined on V79 cells line using neutral red uptake (NRU), nucleic acid content (NAC) and 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction to measure the cellular viability. © 2001 Éditions scientifiques et médicales Elsevier SAS.
Editor: 
Rights: fechado
Identifier DOI: 10.1016/S0223-5234(01)01263-6
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-0035492471&partnerID=40&md5=9a5d4338201c92ce858236cc69cd0c3c
Date Issue: 2001
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File Description SizeFormat 
2-s2.0-0035492471.pdf109.43 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.