Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/948
Type: Artigo de periódico
Title: Post-menopausal hormone therapy reduces autoantibodies to oxidized apolipoprotein B100
Author: CASTANHO, Vera Sylvia
GIDLUND, Magnus
NAKAMURA, Rui
FARIA, Eliana Cotta de
Abstract: The aim of the study was to verify whether post-menopausal hormone replacement therapy (HRT) modifies autoantibody titers against oxidized low-density lipoprotein (LDL) (anti-LDLoxi), against epitopes of oxidized apolipoprotein B100 and common carotid intima-media thickness (IMT) in these women. Sixty-eight women in pre-menopause (PMW) and 216 in post-menopause (POMW) were recruited; eighty-three had undergone HRT for at least 12 months, where 48 received conjugated estrogens alone (EHRT) and 35 received conjugated estrogen and medroxyprogesterone acetate (CHRT). ELISA was used to determine autoantibodies. Lipoprotein lipase (LPL), hepatic lipase (HL), cholesterol ester transfer protein (CETP) and phospholipid transfer protein (PLTP) activities were assayed by radiometric methods. IMT was measured using Doppler ultrasound. Anti-oxidized LDL and anti-D antibodies increased by 40% (p <= 0.003) and 42% (p <= 0.006), respectively, with menopause. There was a surprising and significant 7% reduction in anti-D2 antibody titers with HRT (p <= 0.050), indicating a positive effect of treatment on the immune response to oxidized LDL. Combined HRT decreased activities of HL and LPL. HRT did not change common carotid IMT, which was increased by 32% as expected after menopause (p <= 0.030). This study describes, for the first time, the protective effect of HRT on decreasing autoantibody titers against oxidized apolipoprotein B in LDL.
Subject: Post-menopause hormone replacement therapy
autoantibodies to oxidized LDL
common carotid intima media thickness
HDL-cholesterol
hepatic lipase
atherosclerosis
Country: Estados Unidos
Editor: INFORMA HEALTHCARE
Rights: fechado
Identifier DOI: 10.3109/09513590.2010.526660
Address: http://apps.isiknowledge.com/InboundService.do?Func=Frame&product=WOS&action=retrieve&SrcApp=EndNote&UT=000295617600013&Init=Yes&SrcAuth=ResearchSoft&mode=FullRecord
http://dx.doi.org/10.3109/09513590.2010.526660
Date Issue: 2011
Appears in Collections:FCM - Artigos e Materiais de Revistas Científicas

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