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Type: Artigo de periódico
Title: Extraction Of Indole Alkaloids From Tabernaemontana Catharinensis Using Supercritical Co2+ethanol: An Evaluation Of The Process Variables And The Raw Material Origin
Author: Pereira C.G.
Marques M.O.M.
Barreto A.S.
Siani A.C.
Fernandes E.C.
Meireles M.A.A.
Abstract: Indole alkaloids from Tabernaemontana catharinensis, collected from different places, were extracted using a mixture of supercritical CO2 plus ethanol. The effects of the process variables: temperature, pressure, solvent flow rate, and percentage of cosolvent on the total yield, chemical composition of the extract, and extraction kinetics were determined. The extracts were solvent-partitioned and their composition analyzed by TLC, GC-MS and 1H and 13C NMR. Voacangine and coronaridine were identified as the major compounds in the extracts; the individual alkaloids were quantified by GC-FID using external standard. At 250 bar and 45°C the largest yield (1.29%) and the faster extraction rate were obtained; increasing the percentage of cosolvent improved the extraction rate as well as the yield. Employing an intermittent process consisting in six pressurization- depressurization steps appreciably reduced the total extraction time. © 2003 Elsevier B.V. All rights reserved.
Rights: fechado
Identifier DOI: 10.1016/S0896-8446(03)00112-8
Date Issue: 2004
Appears in Collections:Unicamp - Artigos e Outros Documentos

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