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Type: Artigo de periódico
Title: Increased Serum Levels Of Interleukin-8 In Polyarteritis Nodosa And Behçet's Disease
Author: de Lira Freire A.
Bertolo M.B.
de Pinho Jr. A.J.
Samara A.M.
Muchinechi Fernandes S.R.
Abstract: The pathogenesis of Behçet's disease (BD) and polyarteritis nodosa (PAN) is not yet well established. Endothelial cells have been shown to express chemokines that are involved in inflammatory processes. Interleukin-8 (IL-8) is a potent chemoattractant and activator of neutrophils. We evaluated serum IL-8 levels in patients with PAN and BD. We measured serum IL-8 levels in 21 patients with BD and 16 with PAN. Sera from 30 age-matched healthy blood donors were used as normal controls. Serum IL-8 levels were measured by an enzyme-linked immunosorbent assay (ELISA). The mean serum IL-8 level of the active BD (1522.31 pg/ml) and that of the active PAN (654.8 pg/ml) was significantly higher than that of the normal controls (40.39 pg/ml, P < 0.05). There was no difference in mean serum IL-8 levels between patients with inactive disease and normal controls. We found higher serum levels of IL-8 in those patients with more severe disease. These results suggest that IL-8 may play a role in the pathogenesis of PAN and/or BD. Our study also suggests a possible relation between serum IL-8 levels and the severity of these diseases. © Clinical Rheumatology 2004.
Rights: fechado
Identifier DOI: 10.1007/s10067-003-0851-x
Date Issue: 2004
Appears in Collections:Unicamp - Artigos e Outros Documentos

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