Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/94357
Type: Artigo
Title: Lack of arg972 polymoyphismiIn the Irs1 gene in prakanã Brazilian iIndians
Author: Saad M.J.A.
Bezerra R.M.N.
Menezes R.
Chadid T.T.
Sales T.S.I.
Saad S.T.O.
Altemani C.M.
Soares M.C.P.
Abstract: Several polymorphisms in the insulin receptor substrate-1 (IRS1) gene have been reported in the last years. The most common IRS1 variant, a Gly → Arg substitution at codon 972 (Arg972 IRS1), is more prevalent among subjects who have features of insulin resistance syndrome associated, or not, with type 2 diabetes in European populations. To determine whether the absence of IRS1 polymorphism is a more general characteristic of Paleo-Indian-derived populations, we examined the Arg972 IRS1 polymorphism in Parakanã Indians and found a lack of this polymorphism in the Parakanã population.
Several polymorphisms in the insulin receptor substrate-1 (IRS1) gene have been reported in the last years. The most common IRS1 variant, a Gly → Arg substitution at codon 972 (Arg972 IRS1), is more prevalent among subjects who have features of insulin resistance syndrome associated, or not, with type 2 diabetes in European populations. To determine whether the absence of IRS1 polymorphism is a more general characteristic of Paleo-Indian-derived populations, we examined the Arg972 IRS1 polymorphism in Parakanã Indians and found a lack of this polymorphism in the Parakanã population
Subject: Resistência a insulina
Country: Estados Unidos
Editor: Wayne State University Press
Citation: Human Biology. , v. 76, n. 1, p. 147 - 151, 2004.
Rights: Fechado
Identifier DOI: 10.1353/hub.2004.0015
Address: http://muse.jhu.edu/article/53379
Date Issue: 2004
Appears in Collections:FCM - Artigos e Outros Documentos

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