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Type: Artigo de periódico
Title: Genetic Studies Suggest A Novel Portuguese Origin For Hemoglobin Porto Alegre
Author: Faustina P.
Miranda A.
Picanco I.
Kimura E.M.
Ferreira Costa F.
Sonati M.D.F.
Abstract: Molecular studies performed in Portuguese and Brazilian cases of hemoglobin Porto Alegre [β9 Ser→Cys]Cy's revealed that the mutation is in association with the Mediterranean haplotype I and framework 1 and that it is also in cis with an undescribed intragenic polymorphism (codon 27, GCC→GCT). Based upon these findings, and reinforced by historical data, we suggest that hemoglobin Porto Alegre originated from a single mutational event in the Portuguese population and was then spread to South America, namely to Brazil.
Rights: aberto
Identifier DOI: 
Date Issue: 2004
Appears in Collections:Unicamp - Artigos e Outros Documentos

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