Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/94251
Type: Artigo de periódico
Title: Aluminium Triggers Necrosis And Apoptosis In V79 Cells
Author: Schildknecht P.H.P.A.
Vidal B.C.
Abstract: The aim of this work was to examine the induction of cell death by aluminium (Al) at low pH, where the toxic cation Al3+ has maximum activity. Chinese hamster V79 fibroblasts were used as a model to study the toxic effects of different Al concentrations under optimal conditions for Al3+ activity (pH 4.5). Al3+ was detected by 8-hydroxyquinoline staining and cell death was assessed by image analysis, TUNEL assay and annexin-V labelling. Intracellular Al3+ deposits occurred mainly in the cytoplasm and within the nucleus. Al3+ altered the nuclear morphology, with chromatin condensation and loss being observed in Al3+-treated cells. Necrosis was detected with 10-5- 10-3 M AlCl3 and apoptosis was observed only at 10 -8-10-5 M AlCl3. Our results show that Al 3+ induces cell death through a mechanism which could determine whether necrosis or apoptosis would be triggered.
Editor: 
Rights: fechado
Identifier DOI: 10.1080/62772240410001688251
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-13444288107&partnerID=40&md5=7476f7f91aed3e8360c448b097faab80
Date Issue: 2004
Appears in Collections:Unicamp - Artigos e Outros Documentos

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