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Type: Artigo de evento
Title: Glucocorticoid Receptor And Beta-adrenoceptor Expression In Epididymal Adipose Tissue From Stressed Rats
Author: Farias-Silva E.
Nunes Dos Santos I.
Corezola Do Amaral M.E.
Grassi-Kassisse D.M.
Spadari-Bratfisch R.C.
Abstract: Adipocytes isolated from epididymal adipose tissue of foot-shock stressed rats are supersensitive to isoprenaline and subsensitive to norepinephrine. These alterations are probably mediated by a stress-induced increase in plasma corticosterone levels. We investigated whether foot-shock stress modifies the expression of glucocorticoid receptors (GRs) and β-adrenergic protein receptors (β-ARs) in epididymal adipose tissue from rats submitted to one daily foot-shock session on three consecutive days. This stress protocol caused decreases in GR, β1-AR, and β3-AR protein levels, but caused an increase in β2-AR. These results confirm and support previous functional studies. The alterations in protein expression may be modulated by the high corticosterone levels that downregulate the glucocorticoid receptor.
Rights: fechado
Identifier DOI: 10.1196/annals.1296.040
Date Issue: 2004
Appears in Collections:Unicamp - Artigos e Outros Documentos

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