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|Type:||Artigo de periódico|
|Title:||Naltrexone In Alcohol Dependence: Open Clinical Trial [naltrexona Na Dependência De álcool: Ensaio Clínico Aberto]|
De Azevedo R.C.S.
|Abstract:||Twenty seven male alcohol-dependent patients participated in a six-month open trial of hydrochloride naltrexone (50mg/d)in an outpatient service at HC/Unicamp (Brazil). They were allowed to attend educational and relapse prevention groups. Patients were evaluated eight times during the study. Results: without relapse = 7 (25.9%); ≤ 3 relapses = 4 (14.8%); ≥ 4 relapses, though with an overall decrease in alcohol drinking ≥ 50%) = 7 (25.9%); same pattern of drinking or increased intake = 3 (11.1%); dropouts = 6 (22.2%). Mean number of days to first relapse = 60 (median = 90). Statistical analysis (method of generalized estimation equations) found a significant association between the result abstinence and: regular use of naltrexone (compliance), lessening of alcohol craving score, age of the patients (the younger the better), previous medical treatment for alcohol dependence and decreased levels of γ-CT.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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