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|Type:||Artigo de periódico|
|Title:||Efficacy And Tolerability Of Unsaponifiables Of Avocado And Soy In The Treatment Of Symptomatic Hip And Knee Osteoarthritis [eficácia Sintomática Dos Insaponificáveis De Abacate E Soja (ias) No Tratamento De Osteoartrose (oa) De Quadril E Joelho]|
Da Silva N.A.
|Abstract:||Background: Osteoarthritis (OA) is an idiopathic, multifatorial disease characterized by a progressive and slow loss of articular cartilage. Objectives: To evaluate efficacy and tolerability of unsaponifiables of avocado and soy in the treatment of symptomatic hip and knee OA. Methods: Two hundred and thirty one patients of both sexes were included, aged 45 to 75 years old, that presented hip and/ or knee symptomatic OA. They entered an open label, non-randomized, controlled trial for 6 months. They followed a 15 days washout period for anti-inflammatory drugs (NAIDs). Efficacy was evaluated according to: 1) Lequesne Algo-Funcional Index (IFL) e 2) pain in the Visual Analogue Scale (VAS; 100 mm), NAIDs/analgesics ingestion and total incapacity score (EVA de 100 mm). Results: Two hundred and thirty one patients received IAS. The data for all patients were available in the final evaluation (6 months). The average +/- SEM in the LFI improved from 11,88+/-0,24 to 6,84+/-0,29 in the final evaluation-6 months (p < 0,001). Pain improved from 6,65+/-0,11 mm to 3,21+/-0,17 mm (p= 0,001). NAIDs consumption improved from 1,95+/-0,10 to 0,67+/-0,14 (p <0,001). Success rate was 42,3% in the IAS after 6 months. Tolerance was considered good or excellent. Conclusion: The ASU in this open label controlled multicentric study shown to be effective and safe for the symptomatic pain of AO of the hip and knee. Long term studies are needed to determine the possible mechanisms of action.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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