Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/9393
Type: Artigo de periódico
Title: Neuropatia pela amiodarona: estudo clínico-patológico de dois casos
Title Alternative: Amiodarone neuropathy clinico-pathological study of two cases
Author: Maciel Jr., J. A.
Queiroz, L.
Abstract: Two patients, a 40-year-old woman and a 75-year-old man, were investigated due to a chronic polyneuritis. Amiodarone was used by them to treat refractory cardiac arrythmia since 4 and 6 years before, respectively. The EMG study showed an axonal neuropathy. The light and electronmicroscopical study of sural nerve displayed a losse of large myelinated fibers and a marked reduction of unmyelinated axons, associated with osmiophilic lamellated inclusions in Schwann cells and endothelial venulae. The interruption of amiodarone therapy improved neuropathy. Considered together with similar reports in perhexiline neuropathy and with chloroquine induced neuropathy this would stress the importance of these new drug-induced neurolipidosis.
Dois pacientes, uma mulher de 40 anos e um homem de 75 anos, apresentavam polineurite sensítivo-motora, cujo único antecedente era o uso de amiodarona há 4 e 6 anos respectivamente. O ENMG revelou quadro neuropático tipo axonal. A biópsia do nervo sural mostrou rarefação axonal, mielínica e amielínica, bem como inclusões lamelares osmiofílicas nas células de Schwann e no endotélio venular. Com a retirada da amiodarona houve regressão da polineurite. À semelhança do que foi descrito na neuropatia pelo maleato de perhexiline e pela cloroquina, a amiodarona constitui importante fator de indução de neuro-lipidose medicamentosa.
Editor: Academia Brasileira de Neurologia - ABNEURO
Rights: aberto
Identifier DOI: 10.1590/S0004-282X1989000400016
Address: http://dx.doi.org/10.1590/S0004-282X1989000400016
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1989000400016
Date Issue: 1-Dec-1989
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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