Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/938
Type: Artigo de periódico
Title: Involvement of sensory nerves and TRPV1 receptors in the rat airway inflammatory response to two environment pollutants: diesel exhaust particles (DEP) and 1,2-naphthoquinone (1,2-NQ)
Author: TELES, Aila Mirtes
KUMAGAI, Yoshito
BRAIN, Susan D.
TEIXEIRA, Simone A.
VARRIANO, Ana A.
BARRETO, Maria Alice A. G.
LIMA, Wothan Tavares de
ANTUNES, Edson
MUSCARA, Marcelo N.
COSTA, Soraia K. P.
Abstract: The environmental chemical 1,2-naphthoquinone (1,2-NQ) is implicated in the exacerbation of airways diseases induced by exposure to diesel exhaust particles (DEP), which involves a neurogenic-mediated mechanism. Plasma extravasation in trachea, main bronchus and lung was measured as the local (125)I-bovine albumin accumulation. RT-PCR quantification of TRPV1 and tachykinin (NK(1) and NK(2)) receptor gene expression were investigated in main bronchus. Intratracheal injection of DEP (1 and 5 mg/kg) or 1,2-NQ (35 and 100 nmol/kg) caused oedema in trachea and bronchus. 1,2-NQ markedly increased the DEP-induced responses in the rat airways in an additive rather than synergistic manner. This effect that was significantly reduced by L-732,138, an NK(1) receptor antagonist, and in a lesser extent by SR48968, an NK(2) antagonist. Neonatal capsaicin treatment also markedly reduced DEP and 1,2-NQ-induced oedema. Exposure to pollutants increased the TRPV1, NK(1) and NK(2) receptors gene expression in bronchus, an effect was partially suppressed by capsaicin treatment. In conclusion, our results are consistent with the hypothesis that DEP-induced airways oedema is highly influenced by increased ambient levels of 1,2-NQ and takes place by neurogenic mechanisms involving up-regulation of TRPV1 and tachykinin receptors.
Subject: Neurogenic inflammation
1,2-Naphthoquinone
Diesel exhaust particles
TRPV1 receptor
Rat airways
Capsaicin
Country: Estados Unidos
Editor: SPRINGER
Citation: ARCHIVES OF TOXICOLOGY, v.84, n.2, p.109-117, 2010
Rights: fechado
Identifier DOI: 10.1007/s00204-009-0427-x
Address: http://dx.doi.org/10.1007/s00204-009-0427-x
http://apps.isiknowledge.com/InboundService.do?Func=Frame&product=WOS&action=retrieve&SrcApp=EndNote&UT=000274288600004&Init=Yes&SrcAuth=ResearchSoft&mode=FullRecord
Date Issue: 2010
Appears in Collections:FCM - Artigos e Materiais de Revistas Científicas

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