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dc.typeArtigo de periódicopt_BR
dc.titleEfficacy And Tolerability Of Vigabatrin In West Syndrome [avaliaçao Da Eficácia E Tolerabilidade Da Vigabatrina Na Síndrome De West]pt_BR
dc.contributor.authorMoraes M.H.P.pt_BR
dc.contributor.authorMontenegro M.A.pt_BR
dc.contributor.authorFranzon R.C.pt_BR
dc.contributor.authorAvila J.O.pt_BR
dc.contributor.authorGuerreiro M.M.pt_BR
unicamp.authorMoraes, M.H.P., Departamento de Neurologia, Faculdade de Ciências Médicas, (FCM), Universidade Estudual de Campinas (UNICAMP), Campinas SP, Brazilpt_BR
unicamp.authorMontenegro, M.A., Departamento de Neurologia, Faculdade de Ciências Médicas, (FCM), Universidade Estudual de Campinas (UNICAMP), Campinas SP, Brazilpt_BR
unicamp.authorFranzon, R.C., Departamento de Neurologia, Faculdade de Ciências Médicas, (FCM), Universidade Estudual de Campinas (UNICAMP), Campinas SP, Brazilpt_BR
unicamp.authorÁvila, J.O., Departamento de Neurologia, Faculdade de Ciências Médicas, (FCM), Universidade Estudual de Campinas (UNICAMP), Campinas SP, Brazilpt_BR
unicamp.authorGuerreiro, M.M., Departamento de Neurologia, Faculdade de Ciências Médicas, (FCM), Universidade Estudual de Campinas (UNICAMP), Campinas SP, Brazil, Departamento de Neurologia, FCM/UNICAMP, Caixa Postal 6111, 13083-970 Campinas SP, Brazilpt_BR
dc.description.abstractWest syndrome (WS) is a severe epileptic encephalopathy of childhood, characterized by spasms, developmental deterioration and hipsarhythymia. Objective: To evaluate the safety and efficacy of vigabatrin (VGB) in the treatment of WS. Method: We evaluated every patient diagnosed with WS seen at the pediatric epilepsy clinic and exposed to VGB. Patients were interviewed according to a semistructured questionnaire and we analyzed gender, age, etiology (cryptogenic or symptomatic), associated diseases, age of seizure onset, neuroimaging findings, EEG prior and after VGB, use of other antiepileptic drugs, time for seizure control, electroretinogram, visual complaints, adverse events and family history of epilepsy. Results: Twenty-three patients were evaluated, 16 boys, ages ranging from 1.25 years to 11.5 years (mean=5y3m). Sixteen (69.5%) patients were seizure free, five (22%) had partial seizure control and in two (8.5%) there was no improvement. Only one patient presented gabaergic retinopathy. Six (26%) patients presented adverse events: somnolence, aggressivity or retinopathy. Patients with seizure onset after 6 months of age presented better results after VGB introduction (p<0.05). There was no difference in seizure control according to duration of epilepsy before VGB treatment or etiology of the seizures (p>0.05). After VGB, no patient presented hipsarrhythymia and 50% had a normal EEG. Conclusion: Although VGB may be associated with serious adverse events such as gabaergic retinopathy, our results show that it should be considered in the treatment of WS.en
dc.relation.ispartofArquivos de Neuro-Psiquiatriapt_BR
dc.identifier.citationArquivos De Neuro-psiquiatria. , v. 63, n. 2 B, p. 469 - 473, 2005.pt_BR
dc.description.issuenumber2 Bpt_BR
dc.description.provenanceMade available in DSpace on 2015-06-26T14:09:17Z (GMT). No. of bitstreams: 1 2-s2.0-21744437588.pdf: 153185 bytes, checksum: 41c4ab29f562a25fdeca3750908c9d0a (MD5) Previous issue date: 2005en
dc.description.provenanceMade available in DSpace on 2015-11-26T14:09:09Z (GMT). No. of bitstreams: 2 2-s2.0-21744437588.pdf: 153185 bytes, checksum: 41c4ab29f562a25fdeca3750908c9d0a (MD5) 2-s2.0-21744437588.pdf.txt: 22659 bytes, checksum: 048a51ec76338ec8b60b0ab83c4c728f (MD5) Previous issue date: 2005en
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