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Type: Artigo de periódico
Title: Pharmacovigilance: Comparative Analysis Of Adverse Events Of Antiepileptic Drugs In Childhood [farmacovigilância: Análise Comparativa Dos Eventos Adversos Das Drogas Antiepilépticas Na Infância]
Author: Aquino E.B.
Montenegro M.A.
Guerreiro C.A.M.
Guerreiro M.M.
Abstract: Objective: To compare AED adverse events data obtained from charts with data obtained from interview with parents or caregivers. To correlate the number of adverse events in mono or polytherapy. Methodology: We evaluated 47 consecutive children with epilepsy receiving stable dose of AED for at least three months. Two semi-structured questionnaires were filled out for each child. Statistical analysis was performed using the chi-square test. Results: The analysis showed that somnolence, apathy, irritation, allergy, gum hypertrophy, hair loss and weight change were identified more frequently in direct interview (p < 0.05). There was no difference between the two questionnaires in relation to ataxia, headache, diplopia, learning difficulties, hypertricosis and gastrointestinal complaints. There was no difference between the number of side-effects in mono or polytherapy (p > 0.05). Conclusions: Mild adverse events such as somnolence, apathy, irritation, allergy, gum hypertrophy, hair loss and weight change are underestimated on regular appointments.
Citation: Journal Of Epilepsy And Clinical Neurophysiology. , v. 11, n. 1, p. 15 - 18, 2005.
Rights: aberto
Date Issue: 2005
Appears in Collections:Unicamp - Artigos e Outros Documentos

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