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|Type:||Artigo de evento|
|Title:||Effects Of Manganese Ions In The Neuromuscular Junction|
Dal Belo C.A.
|Abstract:||The neurotoxic effects of manganese occurred mainly from its inhalation are well described in the literature. In this study we have been demonstrated the potent and reversible effect of manganese ions (Mn 2+) on neuromuscular transmission using conventional myographic technique. The Mn 2+ mechanism which causes reversible blockade at neuromuscular junctions was investigated in isolated mouse phrenic nerve-diaphragm (PND) preparations. As much Mn 2+ 0.9 mM as Mn 2+ 1.8 mM produced rapid neuromuscular blockade (50% in < 4 min), but only the lower concentration reversed spontaneously. The use of d-tubocurarine (5.8 μM), 3,4-diaminopyridine (3,4-DAP, 0.09 mM) and dantrolene (10 μM) excluded the involvement of nicotinic receptors, K + channels and ryanodine receptors, respectively, as the potential target for this ion. Manganese acts as an early competitive antagonist and after as an agonist of Ca 2+, indicating that this ion may probably act via Ca 2+ channels.|
|Appears in Collections:||Artigos e Materiais de Revistas Científicas - Unicamp|
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