Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/93605
Type: Artigo de evento
Title: Effects Of Manganese Ions In The Neuromuscular Junction
Author: Oshima-Franco Y.
Leite G.B.
Dal Belo C.A.
Rodrigues-Simioni L.
Abstract: The neurotoxic effects of manganese occurred mainly from its inhalation are well described in the literature. In this study we have been demonstrated the potent and reversible effect of manganese ions (Mn 2+) on neuromuscular transmission using conventional myographic technique. The Mn 2+ mechanism which causes reversible blockade at neuromuscular junctions was investigated in isolated mouse phrenic nerve-diaphragm (PND) preparations. As much Mn 2+ 0.9 mM as Mn 2+ 1.8 mM produced rapid neuromuscular blockade (50% in < 4 min), but only the lower concentration reversed spontaneously. The use of d-tubocurarine (5.8 μM), 3,4-diaminopyridine (3,4-DAP, 0.09 mM) and dantrolene (10 μM) excluded the involvement of nicotinic receptors, K + channels and ryanodine receptors, respectively, as the potential target for this ion. Manganese acts as an early competitive antagonist and after as an agonist of Ca 2+, indicating that this ion may probably act via Ca 2+ channels.
Editor: 
Rights: fechado
Identifier DOI: 
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-27844538722&partnerID=40&md5=409ae2b51cfc414d9ef29f94a17cf4ed
Date Issue: 2005
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.