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Type: Artigo de periódico
Title: Development And Evaluation Of Amoxicillin Formulations By Direct Compression: Influence Of The Adjuvants On Physicomechanical And Biopharmaceutical Properties Of The Tablets
Author: Pasqualoto K.F.M.
Funck J.A.B.
Da Silva F.E.B.
Kratz C.D.P.
Abstract: The amoxicillin 500 mg formulations were developed by direct compression using a 23 factorial design. Eight different formulations were carried out and they were analyzed considering three levels: the type of microcrystalline cellulose (Avicel® PH-102 or Avicel® PH-200), the presence or absence of spray-dried lactose, and the presence or absence of the superdisintegrant agent, croscarmellose sodium. Average weight, thickness and diameter, hardness, friability, amoxicillin concentration (iodometric assay), disintegration time, and dissolution profile were the parameters used for the tablets evaluation. Considering all evaluated parameters, a suitable amoxicillin 500 mg tablet formulation should present the microcrystalline cellulose type Avicel® PH-102 and the superdisintegrant agent, croscarmellose sodium (Ac-disol® SD-711), in its composition.
Rights: fechado
Identifier DOI: 
Date Issue: 2005
Appears in Collections:Unicamp - Artigos e Outros Documentos

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