Please use this identifier to cite or link to this item:
Type: Artigo de evento
Title: Comparison Of Genomic Dna To Cdna Alignment Methods
Author: Galves M.
Dias Z.
Abstract: Aligning cDNA sequences to genomic sequences is a very common way to study expressed sequences, find their genes, and study alternative splicing. Several computer programs address this problem, using heuristics to define exon regions. Usually, standard alignment algorithms are not used to align ESTs to genomic DNA, due to the existence of large regions of introns. This paper compares the EST-to-genomic alignments produced by sim4, est_genome, Spidey and standard sequence aligners using an appropriate score. Surprisingly, standard aligners performed quite well with sequences having few errors. © Springer-Verlag Berlin Heidelberg 2005.
Rights: fechado
Identifier DOI: 
Date Issue: 2005
Appears in Collections:Unicamp - Artigos e Outros Documentos

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