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Type: Artigo de periódico
Title: Abnormal Production Of Transforming Growth Factor β And Interferon γ By Peripheral Blood Cells Of Patients With Multidrug-resistant Pulmonary Tuberculosis In Brazil
Author: Castro A.Z.
Diaz-Bardalez B.M.
Oliveira E.C.
Garcia R.C.
Afiune J.B.
Paschoal I.A.
Santos L.M.B.
Abstract: Objective. The aim of the present study was to determine the immune response profile that differentiates patients with newly diagnosed (non-treated) pulmonary tuberculosis from multidrug-resistant (MDR) ones, as well as from healthy, tuberculin positive individuals. Methods. Lymphocytes proliferative response to non-specific mitogen (PHA) and PPD were evaluated by 3H thymidine incorporation and cytokines were quantified using an ELISA assay. Results. Patients with active disease showed a diminished proliferative response to PHA and PPD, while multidrug-resistant patients showed a diminished proliferative response to PHA, but a normal response to PPD. The cytokine production of newly diagnosed patients was characterized by a diminished production of IFNγ and normal production of transforming growth factor (TGFβ), while MDR patients revealed a normal production of IFNγ accompanied by an increase in TGFβ. Conclusions. The production of significant amounts of TGFβ in MDR patients leads to a poor immune response and may contribute to the resistance of tuberculosis patients to drugs. © 2005 The British Infection Society. Published by Elsevier Ltd. All rights reserved.
Rights: fechado
Identifier DOI: 10.1016/j.jinf.2004.08.035
Date Issue: 2005
Appears in Collections:Unicamp - Artigos e Outros Documentos

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