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Type: Artigo de periódico
Title: 32 Factorial Design And Response Surface Analysis Optimization Of N-carboxybutylchitosan Synthesis
Author: Dos Santos K.S.C.R.
Silva H.S.R.C.
Ferreira E.I.
Bruns R.E.
Abstract: A 32. factorial design investigation to optimize N-carboxybutylchitosan was carried out varying the levulinic acid/chitosan molar ratio between 1.00 and 3.00 and the sodium borohydride/chitosan molar ratio from 0.50 to 1.00. 1H NMR spectra signals at 1.0 and 2.5 ppm were used to monitor the reaction system. A quadratic model having significant terms for both molar ratios was found for N-carboxybutylchitosan substitution degree whereas a linear model best describes the substitution degree of 5-methylpyrrolidinone chitosan. Maximum N-carboxybutylchitosan and minimum 5-methylpyrrolidinone chitosan substitution degrees occur for levulinic acid/chitosan molar ratios between 2.00 and 3.00 and a 0.50 for sodium borohydride/chitosan molar ratio. © 2004 Elsevier Ltd. All rights reserved.
Rights: fechado
Identifier DOI: 10.1016/j.carbpol.2004.08.020
Date Issue: 2005
Appears in Collections:Unicamp - Artigos e Outros Documentos

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