Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/93208
Type: Artigo de periódico
Title: Parafac: A Chemometric Tool For Multi-dimensional Data Treatment. Applications In Direct Determination Of Drugs In Human Plasma By Spectrofluorimetry [parafac: Uma Ferramenta Quimiométrica Para Tratamento De Dados Multidimensionais. Aplicações Na Determinação Direta De Fármacos Em Plasma Humano Por Espectrofluorimetria]
Author: Sena M.M.
Trevisan M.G.
Poppi R.J.
Abstract: Since the last decade, the combined use of chemometrics and molecular spectroscopic techniques has become a new alternative for direct drug determination, without the need of physical separation. Among the new methodologies developed, the application of PARAFAC in the decomposition of spectrofluorimetric data should be highlighted. The first objective of this article is to describe the theoretical basis of PARAFAC. For this purpose, a discussion about the order of chemometric methods used in multivariate calibration and the development of multi-dimensional methods is presented first. The other objective of this article is to divulge for the Brazilian chemical community the potential of the combination PARAFAC/spectrofluorimetry for the determination of drugs in complex biological matrices. For this purpose, two applications aiming at determining, respectively, doxorrubicine and salicylate in human plasma are presented.
Editor: 
Rights: aberto
Identifier DOI: 
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-30744450227&partnerID=40&md5=6650075a28e3ed8557b5434aca792ed2
Date Issue: 2005
Appears in Collections:Unicamp - Artigos e Outros Documentos

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