Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/93075
Type: Artigo de periódico
Title: Synthesis Of 4-aryl-2-pyrrolidones And β-aryl-γ-amino-butyric Acid (gaba) Analogues By Heck Arylation Of 3-pyrrolines With Arenediazonium Tetrafluoroborates. Synthesis Of (±)-rolipram On A Multigram Scale And Chromatographic Resolution By Semipreparative Chiral Simulated Moving Bed Chromatography
Author: Garcia A.L.L.
Carpes M.J.S.
De Oca A.C.B.M.
Dos Santos M.A.G.
Santana C.C.
Correia C.R.D.
Abstract: (Chemical Equation Presented) We report herein a new, practical, and economic synthesis of the phosphodiesterase inhibitor Rolipram on a multigram scale as well as the synthesis of new 4-aryl pyrrolidones and β-aryl-γ-amino butyric acids (GABA derivatives) employing an efficient Heck-Matsuda arylation of 3-pyrroline with aryldiazonium tetrafluoroborates. Racemic Rolipram was resolved into its enantiomers using chiral simulated moving bed chromatography having the low-cost microcrystalline cellulose triacetate as a chiral stationary phase.
Editor: 
Rights: fechado
Identifier DOI: 10.1021/jo0484880
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-13244298300&partnerID=40&md5=15e9012c9a250c05d284e50391f7dab2
Date Issue: 2005
Appears in Collections:Unicamp - Artigos e Outros Documentos

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