Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/93038
Type: Artigo de periódico
Title: Molecular And Cellular Mechanisms That Lead To Candida Biofilm Formation
Author: Ten Cate J.M.
Klis F.M.
Pereira-Cenci T.
Crielaard W.
De Groot P.W.J.
Abstract: Fungal infections in the oral cavity are mainly caused by C. albicans, but other Candida species are also frequently identified. They are increasing in prevalence, especially in denture-wearers and aging people, and may lead to invasive infections, which have a high mortality rate. Attachment to mucosal tissues and to abiotic surfaces and the formation of biofilms are crucial steps for Candida survival and proliferation in the oral cavity. Candida species possess a wide arsenal of glycoproteins located at the exterior side of the cell wall, many of which play a determining role in these steps. In addition, C. albicans secretes signaling molecules that inhibit the yeast-to-hypha transition and biofilm formation. In vivo, Candida species are members of mixed biofilms, and subject to various antagonistic and synergistic interactions, which are beginning to be explored. We believe that these new insights will allow for more efficacious treatments of fungal oral infections. For example, the use of signaling molecules that inhibit biofilm formation should be considered. In addition, cell-wall biosynthetic enzymes, wall crosslinking enzymes, and wall proteins, which include adhesins, proteins involved in biofilm formation, fungal-bacterial interactions, and competition for surface colonization sites, offer a wide range of potential targets for therapeutic intervention.
Editor: 
Rights: fechado
Identifier DOI: 10.1177/0022034508329273
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-62649146443&partnerID=40&md5=955f0671b83e2f74986ffbd8691009ff
Date Issue: 2009
Appears in Collections:Unicamp - Artigos e Outros Documentos

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