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Type: Artigo de periódico
Title: Novel Supramolecular Palladium Catalyst For The Asymmetric Reduction Of Imines In Aqueous Media
Author: Da Silva W.A.
Rodrigues Jr. M.T.
Shankaraiah N.
Ferreira R.B.
Andrade C.K.Z.
Pilli R.A.
Santos L.S.
Abstract: A novel approach to the asymmetric reduction of dihydro-β-carboline derivatives to the corresponding tetrahydro-β-carbolines is described based on the supramolecular lyophilized complex formed from β-cyclodextrin/ imines as an enzyme mimetic and palladium hydride as the reducing agent. The methodology allowed us to develop a short and efficient preparation of (R)-harmicine and (R)-deplancheine alkaloids in high overall yields and ee of 89 and 90%, respectively. © 2009 American Chemical Society.
Rights: fechado
Identifier DOI: 10.1021/ol9011772
Date Issue: 2009
Appears in Collections:Unicamp - Artigos e Outros Documentos

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