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Type: Artigo de periódico
Title: Soybean and sunflower oil-induced insulin resistance correlates with impaired GLUT4 protein expression and translocation specifically in white adipose tissue
Author: POLETTO, Ana Claudia
ANHE, Gabriel Forato
TAKAHASHI, Hilton Kenji
FURUYA, Daniela Tomie
OKAMOTO, Maristela Mitiko
MACHADO, Ubiratan Fabres
Abstract: Free fatty acids are known for playing a crucial role in the development of insulin resistance. High fat intake is known for impairing insulin sensitivity; however, the effect of vegetable-oil injections have never been investigated. The present study investigated the effects of daily subcutaneous injections (100 mu L) of soybean (SB) and sunflower (SF) oils, during 7 days. Both treated groups developed insulin resistance as assessed by insulin tolerance test. The mechanism underlying the SB- and SF-induced insulin resistance was shown to involve GLUT4. In SB- and SF-treated animals, the GLUT4 protein expression was reduced similar to 20% and 10 min after an acute it? vivo stimulus with insulin, the plasma membrane GLUT4 content was similar to 60% lower in white adipose tissue (WAT). No effects were observed in skeletal muscle. Additionally, both oil treatments increased mainly the content of palmitic acid (similar to 150%) in WAT, which can contribute to explain the GLUT4 regulations. Altogether, the present study collects evidence that those oil treatments might generate insulin resistance by targeting GLUT4 expression and translocation specifically in WAT. These alterations are likely to be caused due to the specific local increase in saturated fatty acids that occurred as a consequence of oil daily injections. Copyright (C) 2010 John Wiley & Sons, Ltd.
Subject: GLUT4
fatty acids
insulin resistance
soybean oil
sunflower oil
Country: Inglaterra
Citation: CELL BIOCHEMISTRY AND FUNCTION, v.28, n.2, p.114-121, 2010
Rights: fechado
Identifier DOI: 10.1002/cbf.1628
Date Issue: 2010
Appears in Collections:FCM - Artigos e Outros Documentos

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