Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/92903
Type: Artigo de periódico
Title: Effect Of Conjugated Linoleic Acid Supplementation On Lipoprotein Lipase Activity In 3t3-l1 Adipocyte Culture [efeito Da Suplementação Com ácido Linoléico Conjugado Sobre A Atividade Da Lípase Lipoprotéica Em Cultura De Adipócitos 3t3-l1]
Author: Botelho A.P.
Santos-Zago L.F.
de Oliveira A.C.
Abstract: Supplementation with conjugated linoleic acid may reduce fat body mass and increase lean body mass in various species. Some studies have demonstrated that conjugated linoleic acid reduces body fat, in part, by inhibiting the activity of lipoprotein lipase in adipocytes. The objective of this work was to study the effect of conjugated linoleic acid supplementation on lipoprotein lipase activity in 3T3-L1 adipocyte culture. 3T3-L1 adipocytes received linoleic acid (group C) or conjugated linoleic acid (group AE, supplemented with AdvantEdge® CLA, and group CO, supplemented with CLA One®) in concentrations of 1 mmol/L. Heparin-releasable lipoprotein lipase activity was analyzed by means of a 3T3-L1 adipocyte culture. After 7 days, heparin-releasable lipoprotein lipase activity was lower in the groups AE and CO supplemented with conjugated linoleic acid. These results suggest that one of the mechanisms by which CLA is capable of reducing body fat is by reducing lipoprotein lipase activity.
Editor: 
Rights: aberto
Identifier DOI: 10.1590/S1415-52732009000500017
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-77949417890&partnerID=40&md5=e3c6e5b693f26b9b81b6a652884c1147
Date Issue: 2009
Appears in Collections:Unicamp - Artigos e Outros Documentos

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