Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/92817
Type: Artigo de periódico
Title: Determination Of The Vectorelectrogram In Isolated Rat Atria: Application To The Study Of Arrhythmias.
Author: Zafalon N.
Bassani J.W.
Bassani R.A.
Abstract: Atrial tachyarrhythmias, the most frequent type of cardiac arrhythmia, are associated with increased stroke risk. Reentry and focal activity are considered as the main mechanisms underlying this dysfunction. In this study, we describe determination of the vectorelectrogram in isolated rat atria as a means to distinguish different patterns of electrical propagation. In all studied right atria beating at sinus rhythm, the mean electric vector (MEV) trajectory was clockwise, and each cycle was preceded by electric diastole (null MEV), either in the absence or presence of muscarinic cholinergic or beta-adrenergic receptor stimulation. During cholinergic tachyarrhythmia (induced by high-rate electric stimulation in both atria, plus exposure to carbachol in left atria), vector loops were ellipsoidal and stable, with variable direction, and did not cross the origin, which is consistent with reentrant activation and with findings obtained in vivo by other authors. In contrast, during spontaneous activity induced by rapid pacing in isoproterenol-exposed left atria, vector loops were similar to those in right atria at sinus rhythm, thus suggestive of focal activity. It is concluded that the vectorelectrogram approach allows discrimination of different patterns of propagation during arrhythmia in isolated atria and may be useful for high-output tests of pro- and anti-arrhythmic compounds.
Editor: 
Rights: fechado
Identifier DOI: 
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-77954980499&partnerID=40&md5=3980b0a903361404ab82441008915a22
Date Issue: 2009
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File Description SizeFormat 
2-s2.0-77954980499.pdf503.48 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.