Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/92702
Type: Artigo de periódico
Title: Estrogen Replacement Avoids The Decrease Of Bladder Innervations In Ovariectomized Adult Virgin Rats: In Vivo Stereological Study
Author: de Fraga R.
Palma P.
Dambros M.
Riccetto C.L.Z.
Mandarim-de-Lacerda C.
Miyaoka R.
Abstract: Introduction and hypothesis: The authors quantified the nerve fibers in the bladder wall of ovariectomized rats with and without estradiol replacement. Methods: This study was conducted on 40 Wistar rats (3 months old). Group 1: remained intact; Group 2: underwent bilateral ovariectomy, and after 30 days was started on subcutaneous sesame oil replacement (0.2 ml per day) for 90 days; Group 3: sham-operated, and after 30 days was started on subcutaneous sesame oil replacement (0.2 ml per day) for 90 days; Group 4: bilateral ovariectomy, and after 30 days was started on subcutaneous injection of 17β-estradiol (10 μg/kg body weight) for 90 days. S-100 was used to stain nerves myelinized fibers on paraffin rat bladder sections. The G-50 grid system was used to quantitatively analyze the fibers. Conclusion: Long-term estrogen deprivation caused significant changes in bladder innervations, which can be characterized by a decreased number of nerve fibers by 65% (p < 0.001). © The International Urogynecological Association 2009.
Editor: 
Rights: fechado
Identifier DOI: 10.1007/s00192-009-0811-3
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-63749128987&partnerID=40&md5=52ba3d3801ce2489662dff2a174192dc
Date Issue: 2009
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.