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|Type:||Artigo de periódico|
|Title:||Estrogen Replacement Avoids The Decrease Of Bladder Innervations In Ovariectomized Adult Virgin Rats: In Vivo Stereological Study|
|Author:||de Fraga R.|
|Abstract:||Introduction and hypothesis: The authors quantified the nerve fibers in the bladder wall of ovariectomized rats with and without estradiol replacement. Methods: This study was conducted on 40 Wistar rats (3 months old). Group 1: remained intact; Group 2: underwent bilateral ovariectomy, and after 30 days was started on subcutaneous sesame oil replacement (0.2 ml per day) for 90 days; Group 3: sham-operated, and after 30 days was started on subcutaneous sesame oil replacement (0.2 ml per day) for 90 days; Group 4: bilateral ovariectomy, and after 30 days was started on subcutaneous injection of 17β-estradiol (10 μg/kg body weight) for 90 days. S-100 was used to stain nerves myelinized fibers on paraffin rat bladder sections. The G-50 grid system was used to quantitatively analyze the fibers. Conclusion: Long-term estrogen deprivation caused significant changes in bladder innervations, which can be characterized by a decreased number of nerve fibers by 65% (p < 0.001). © The International Urogynecological Association 2009.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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