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Type: Artigo de periódico
Title: Bioreduction Of α-chloroacetophenone By Whole Cells Of Marine Fungi
Author: Rocha L.C.
Ferreira H.V.
Pimenta E.F.
Berlinck R.G.S.
Seleghim M.H.R.
Javaroti D.C.D.
Sette L.D.
Bonugli R.C.
Porto A.L.M.
Abstract: The asymmetric reduction of 2-chloro-1-phenylethanone (1) by seven strains of marine fungi was evaluated and afforded (S)-(-)-2-chloro-1-phenylethanol with, in the best case, an enantiomeric excess of 50% and an isolated yield of 60%. The ability of marine fungi to catalyse the reduction was directly dependent on growth in artificial sea water-based medium containing a high concentration of Cl- (1.2 M). When fungi were grown in the absence of artificial sea water, no reduction of 1 by whole cells was observed. The biocatalytic reduction of 1 was more efficient at neutral rather than acidic pH values and in the absence of glucose as co-substrate. © 2009 Springer Science+Business Media B.V.
Rights: fechado
Identifier DOI: 10.1007/s10529-009-0037-y
Date Issue: 2009
Appears in Collections:Unicamp - Artigos e Outros Documentos

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