Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/92205
Type: Artigo de periódico
Title: Chiral Chromatographic Separation Of Anesthetics From Dilute And Concentrated Solutions Under Preparative Scale [separação Cromatográfica Quiral De Anestésicos A Partir De Soluções Diluídas E Concentradas Em Escala Preparativa]
Author: Da Silva Jr. I.J.
Barreto Jr. A.G.
Santana C.C.
Abstract: In this work the separation of the chiral anesthetic compounds ketamine and bupivacaine was development using two chiral stationary phases (CSP). Ketamine enantiomers were well separate in the polysaccharide-based CSP (microcrystalline cellulose triacetate - MCTA) while bupivacaine in the tartardiamide-based CSP (Kromasil CHI-TBB). In both cases, the effect of temperature was investigated under analytical conditions. An improvement in the separation performance with temperature was observed. Thermodynamic parameters were evaluated by the van't Hoff plot. We concluded that enthalpic effects controlled the retention in these chiral columns. The enantiomers of ketamine and bupivacaine were separated under overloaded conditions with a good performance.
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Rights: aberto
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Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-66749148857&partnerID=40&md5=f235276b2b5faeb4faa4fd2694493589
Date Issue: 2009
Appears in Collections:Unicamp - Artigos e Outros Documentos

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