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Type: Artigo de periódico
Title: Delayed Graft Function In Renal Transplant Recipients: Risk Factors And Impact On 1-year Graft Function: A Single Center Analysis
Author: Bronzatto E.J.M.
da Silva Quadros K.R.
Santos R.L.S.
Alves-Filho G.
Mazzali M.
Abstract: Delayed graft function (DGF), a frequent complication after kidney transplantation, occurs among about 60% of recipients of kidneys from deceased donors. DGF has a multifactorial etiology. It is characterized by acute tubular necrosis (ATN) upon biopsy. In this study we sought to identify among a group of recipients of kidneys from deceased donors, the incidence, risk factors, and impacts on patient and graft survivals of DGF. Materials and Methods: We retrospectively analyzed medical records from renal transplant recipients aged >18 years who received a deceased donor kidney graft between January 2003 and December 2006. Kidneys lost during the first week posttransplantation were excluded from this series. Results: Among 165 transplants, 111 (67%) displayed DGF, defined as the need for dialysis during the first week posttransplantation. The incidence of DGF was higher among patients with a cold ischemia time (CIT) > 24 hours: 85% vs 60%, DGF vs no DGF (P < .05), as well as for grafts from older donors. After 1-year follow-up, the DGF group showed worse graft function (serum creatinine 1.6 ± 0.7 vs 1.3 ± 0.4 mg/dL; P < .05) as well as a greater incidence of graft loss. Conclusion: Prolonged cold ischemia and older donor age were associated with a greater incidence of DGF in this series, leading to prolonged hospitalization, increased risk for an acute rejection episode, and reduced graft function and survival after 1 year. © 2009 Elsevier Inc. All rights reserved.
Rights: fechado
Identifier DOI: 10.1016/j.transproceed.2009.02.004
Date Issue: 2009
Appears in Collections:Unicamp - Artigos e Outros Documentos

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