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Type: Artigo de periódico
Title: Up-regulation Of Plasminogen Activator Inhibitor-2 Is Associated With High-risk Hpv And Grade Of Cervical Lesion At Baseline But Does Not Predict Outcomes Of High-risk Hpv Infections Or Incident Cin
Author: Syrjanen S.
Naud P.
Sarian L.
Derchain S.
Roteli-Martins C.
Longatto-Filho A.
Tatti S.
Branca M.
Erzen M.
Hammes L.S.
Costa S.
Syrjanen K.
Abstract: Protease inhibitor serpin-B2 (plasminogen activator inhibitor-2 [PAI-2]) protects pRb from degradation in human papillomavirus (HPV)-18+ HeLa cells. Our objective was to assess whether the pRb-mediated HPV-suppressive effect of PAI-2 in cancer cell lines has implications in the outcome of HPV infections. Cervical biopsy specimens from 225 women were analyzed for PAI-2 expression to assess its value as a predictor of cervical intraepithelial neoplasia (CIN) grade, high-risk (HR) HPV at baseline, outcomes of HR-HPV infections, and the development of incident CIN. PAI-2 expression increased in parallel with lesion grade. Nuclear PAI-2 expression was significantly related to HR-HPV detection and had a linear relationship with HR-HPV load. PAI-2 expression was of no value in predicting the outcomes of HR-HPV infections. The same was true for PAI-2 as a predictor of surrogate end points (incident CIN 1+, CIN 2+) of progressive disease. PAI-2 expression is up-regulated on transition from CIN 2 to CIN 3. The HR-HPV suppressive effects of PAI-2 were not related to more favorable outcomes of HR-HPV infections or lower risk of disease progression to CIN. © American Society for Clinical Pathology.
Rights: fechado
Identifier DOI: 10.1309/AJCPQQ07WUTZUTES
Date Issue: 2009
Appears in Collections:Unicamp - Artigos e Outros Documentos

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