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|Type:||Artigo de periódico|
|Title:||Subcutaneous Angiogenesis In Patients Undergoing Plastic Surgery Procedures After Weight-reducing Gastroplasty: A Reason For Increased Bleeding During Intra- And Postoperative Periods?|
|Abstract:||Plastic surgery procedures performed in patients who previously underwent weight-reducing gastroplasty present a high risk for medical complications, one of the most severe being bleeding during the perioperative period. Although the cause of this bleeding is currently unknown, it is postulated that these patients may present an increase in microvascular density and/or in the diameter of subcutaneous vessels. The aim of this study was to evaluate and compare the number and the caliber of subcutaneous vessels in two groups of patients undergoing abdominoplasty, one of them with a history of previous weight-reducing gastroplasty (group I) and the other without this feature (group II). Each group was composed of ten female subjects. During the surgeries, samples of subcutaneous adipose tissue were collected from six different abdominal topographies in each patient. Subcutaneous vessels were assessed by immunohistochemistry using the pan-endothelial marker CD34 and quantified through the variables "microvessel density (MVD), percentage (%EndA), and mean (MEndA) endothelial areas" using computer-assisted technology. Total intraoperative bleeding volume was significantly greater in group I. However, there were no statistically significant differences among the MVD values obtained neither from different abdominal sub-regions nor between groups I and II regarding the values of MVD, %EndA, and MEndA. The greater bleeding observed in patients with a past history of weightreducing gastroplasty could not be explained by greater vascularity nor by the presence of vessels with larger calibers in the subcutaneous tissue of these patients. © Springer-Verlag 2010.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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